Haemophilus influenzae
Microbiology
| Feature | Type b Strains | Nontypable Strains |
| Capsule | Ribosyl-ribitol phosphate | Unencapsulated |
| Pathogenesis | Invasive infections due to hematogenous spread | Mucosal infections due to contiguous spread |
| Clinicalmanifestations | Meningitis and invasive infections in incompletely immunized infants and children | Otitis media in infants and children; lower respiratory tractinfections in adults with chronic bronchitis |
| Evolutionaryhistory | Basically clonal | Genetically diverse |
| Vaccine | Highly effective conjugate vaccines | Under development |
Epidemiology and transmission
Pathogenesis
Immune response
Clinical manifestations
- Hib
- Nontypable H.influenzae
Diagnosis
Treatment
- Hib
- 3rd cepha (eg., IV cefotaxim/ceftriaxone)
- Nontypable H.influenza
- PO amoxicillin/clavulanic acid, cephalosporins, new macrolide
Prevention
- Vaccination
- Chemoprophylaxis
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