Introduction
Definition
Etiology
Epidemiology
Pathogenesis
Puncture wound -> motor neurons -> spinal cord interneurons
Tetanospasmin: cleaves SNARE -> blocks releasing of inhibitory NTs (glycine & GABA)
Approach to the patient
Clinical manifestations
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Symmetric, descending paralysis start with cranial nerve abnormalities
Diplopia, dysphagia, dysphonia
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Diagnosis
Treatment
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??? + ????? (diazepam)
TOC ? Metronidazole. Penicillin, ??? Tetracycline
Prognosis
Prevention
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???? (Td? 3?)
? 7? ??? Td ?? DTaP, 9??? ??? Tdap? ??.
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10? ???? ?? 3? ??? ?? ‘T’ (vaccine)
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5? ???? ‘T’, ?? 3? ????? ‘T’ + ‘TIG’
7? ??: T/Td ?? DTaP or DT ???? ??.
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