Overview
Diagnosis
Preparation
Clinical considerations
ACEi/ARB
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00003-5/fulltext
- Concern
- SARS-CoV-2 gains entry into cells by binding to a ACE2
- ACEi/ARB could lead to increased cellular expression of ACE2
- Counter hypothesis
- Might actually protect against severe outcomes from COVID-19 by upregulating ACE2, resulting in protective, anti-inflammatory effects in the lung.
- Result
- REPLACE COVID trial – no difference
- BRACE CORONA study – no difference
Vasculitis
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30420-3/fulltext
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