S5 Gram-Negative Bacterial Infections

C218 Neisseria meningitidis (Meningococcus)

C219 Neisseria gonorrhoeae (Gonococcus)

C220 Kingella kingae

C221 Haemophilus influenzae

Etiology

Epidemiology

Pathophysiology

Diagnosis

Clinical manifestations and treatment

Meningitis

Cellulitis

Supraglottitis or acute epiglottitis

tripod position epiglottitis ??? ????

Pneumonia

Suppurative Arthritis

Pericarditis

Bacteremia Without an Associated Focus

Miscellaneous Infections

Invasive Disease in Neonates

Otitis Media

Conjunctivitis

Sinusitis

Prevention

C222 Chancroid (Haemophilus ducreyi)

C223 Moraxella catarrhalis

C224 Pertussis (Bordetella pertussis and Bordetella parapertussis)

Harrison C155

Severe cough with apnea and posttussive emesis in paroxysmal phase.

C225 Salmonella

C226 Shigella

Etiology

  • Ingestion of contaminated food/water
  • Outbreaks (eg, day care)

Epidemiology

Pathogenesis

Immunity

Clinical manifestations and complications

  • High fever, intestinal cramping,
  • Stools that are initially watery before developing mucus and/or blood.
  • Complications
    • HUS
      • Lless common than E.coli O157:H7
    • Seizure in children
      • By fever from the infection (ie, febrile siezure)
      • By enterotoxins produced by the organism itself.
    • Rectal prolapse d/t severe rectal inflammation
    • Bacteremia

Differential diagnosis

Diagnosis

  • Stool culture

Treatment

  • Supportive care
  • Antibiotics if severe

Prevention

C227 Escherichia coli

Enterotoxigenic Escherichia coli

Enteroinvasive Escherichia coli

Enteropathogenic Escherichia coli

Shiga Toxin–Producing Escherichia coli

Hemolytic uremic syndrome (HUS) is a complication thata occurs in <10% of patients with STEC. m/c in children age <5.
The risk of HUS is increased in patients who have received antibiotics or antimotility agents (eg, loperamide) to treat tthe diarrhea.

Treatament of E.coli O157:H7 infection is supportive carae only (eg, rehydration)

Enteroaggregative Escherichia coli

Diffusely Adherent Escherichia coli

Enteroaggregative Hemorrhagic Escherichia coli

Diagnosis

Treatment

Prevention of Illness

C228 Cholera

C229 Campylobacter

C230 Yersinia

C231 Aeromonas and Plesiomonas

C232 Pseudomonas, Burkholderia, and Stenotrophomonas

C233 Tularemia (Francisella tularensis)

C234 Brucella

C235 Legionella

C236 Bartonella

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