Medical Archive

Name	??	Tags	??	??
?????	??, ???, ???	??	1/2/3	NSAID (??? ?? ???. eg, rebamipid, PPI)
????		??	1/3/3	Acetaminophen
????		??	1/3/3	Streptokinase
????	??	??	1/3/3	??
????		??	1/3/3	??
???		??	2/3/3	??, ??
???	??	??	1/3/3	???. Acetylcystein
????	???	??	1/3/3
???	??	??	1/1/3

?? – ??? (antitussives)

????? ???? ??? ??? ??: up regulation of NMDA receptor
? antagonizes NMDA glutamate receptors

• ??? ??
  • Narcotic opioids
    • Morphine, codeine, hydrocodone
    • ???? ?? ??, ??, ??, ????, ??
  • Non-narcotic opioids
    • Dextromethrophan; weak NMDA antagonist
  • Nonopioids
  • ??????: dextromethorphan + ephedrine + pheniramine
  • ????: dextromethorphan ?? codeine -> ?? ?? ??.
  • ?????: ??? codeine + guaifenesin
• ??? ??
  • Levodropropizine ????, ?? ?? ? C-fiber ??.
    24?? ?? ???, ?? ??? ?? ? ??
  • Guaifenesin ?? ???? ??. ?? ?? ????? ??? ?? ??? ???? ??.
• ? ?
  • 1?? ?????
    • CNS ????, ????? ??.
  • ???? (e.g., ipratropium bromide ???)

??? (mucoactive drugs)

https://err.ersjournals.com/content/19/116/127#sec-2

??? (expectorants)

??? ???? ?? ?? ???? ?????.
An agent that induces discharge or expulsion of mucus from the respiratory tract

• Hypertonic saline
• Iodine-containing compounds
• Guaifenesin (glyceryl guaiacolate)
• Ion channel modifiers
  • Tricyclic nucleotides
    • Regulate ion transport through P2Y2 purinergic receptors that increase intracellular calcium
  • Nebulised uridine triphosphate aerosol

Mucoregulators

Drugs that regulate mucus secretion or interfere with the DNA/F-actin network

• Carbocysteine
  • S-Carboxymethylcysteine (SCMC-Lys)
• Anticholinergic agents
• Glucocorticoids
• Macrolide antibiotics

????? (mucolytics)

Liquifies mucus by disrupting disulfide bonds.
?? ?????? ??? ?? ???. ??? ?? ?? ??? ???.

• N-acetylcysteine (NAC)
  • e.g., ???, ????
  • ??? ??? ???? ??.
• Erdostein
  • e.g., ???
  • ??? ???? cystein ????. ?? ???? ??.
• Peptide mucolytics
  • Lysozyme, streptodornase, dornase alpha
  • ?? ??? ???? ?? ?? ??.
• Non-destructive mucolytics
• Bromhexine
  • e.g., ???

Mucokinetics

The majority of mucokinetic agents (sometimes referred to as cough clearance promoters) increase mucociliary clearance by acting on the cilia.

• Bronchodilators
  • ß2 agonist: ??? ??, ?? ?? ?? ??, ???? ????.
• Ambroxol
  • Stimulate surfactant and mucus secretion

???

http://www.ksid.or.kr/file/2017_49_4_ko.pdf

????(oseltamivir)

??: qd, 10? ??: bid, 5?

JX999 ?? ??

• ????: 48?? ? ??? ?? ?? ????? ?? ??, (???? ???) ???? ? ????
• ????: 48?? ? ??? ?? ?? ????? ?? ??, ????? ?? ?? ??.

??

Nasal spray

Mometasone furoate 60?, 140? – “????”