Medical Archive

Perez I77 Endometrial Cancer – Intro

Anatomy

Epidemiology and Risk Factors

Clinical Presentation and Natural History

Diagnostic Workup

Pathologic Classification

Endometrial Hyperplasia

Carcinoma of the Endometrium

Molecular Biology

Figure 77.4 Genomic landscape of endometrial cancer. a, Mutation frequencies (vertical axis, top panel) plotted for each tumour (horizontal axis). Nucleotide substitutions are shown in the middle panel, with a high frequency of C-to-A transversions in the samples with POLE exonuclease mutations. CN, copy number. b, Tumours were stratified into the four groups by (1) nucleotide substitution frequencies and patterns, (2) MSI status, and (3) copy-number cluster. SNV, single nucleotide variant. c, POLE-mutant tumours have significantly better progression-free survival, whereas copy-number high tumours have the poorest outcome. d, Recurrently mutated genes are different between the four subgroups. Shown are the mutation frequencies of all genes that were significantly mutated in at least one of the four subgroups (MUSiC, asterisk denotes FDR < 0.05).

POLE necessitates genetic test

2028 PORTEC
2030 RAINBOW

Retrospective study by SNUBH & SNUH

Molecular subtype

분류가 안된 사람도 있고 해서 결과가 잘 안나왔다.